Membrane topology analysis of HIV-1 envelope glycoprotein gp41
نویسندگان
چکیده
منابع مشابه
Core Structure of gp41 from the HIV Envelope Glycoprotein
The envelope glycoprotein of human immunodeficiency virus type 1 (HIV-1) consists of a complex of gp120 and gp41. gp120 determines viral tropism by binding to target-cell receptors, while gp41 mediates fusion between viral and cellular membranes. Previous studies identified an alpha-helical domain within gp41 composed of a trimer of two interacting peptides. The crystal structure of this comple...
متن کاملConformational changes in HIV-1 gp41 in the course of HIV-1 envelope glycoprotein-mediated fusion and inactivation.
HIV-1 envelope glycoprotein-mediated fusion is driven by the concerted coalescence of the HIV-1 gp41 N- and C-helical regions, which results in the formation of 6-helix bundles. These two regions are considered prime targets for peptides and antibodies that inhibit HIV-1 entry. However, the parameters that govern this inhibition have yet to be elucidated. We address this issue by monitoring the...
متن کاملCoevolution Analysis of HIV-1 Envelope Glycoprotein Complex.
The HIV-1 Env spike is the main protein complex that facilitates HIV-1 entry into CD4+ host cells. HIV-1 entry is a multistep process that is not yet completely understood. This process involves several protein-protein interactions between HIV-1 Env and a variety of host cell receptors along with many conformational changes within the spike. HIV-1 Env developed due to high mutation rates and pl...
متن کاملCorrection: Coevolution Analysis of HIV-1 Envelope Glycoprotein Complex.
Copyright: © 2015 Rawi et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
متن کاملStructural plasticity in the topology of the membrane-interacting domain of HIV-1 gp41.
We use a number of computational and experimental approaches to investigate the membrane topology of the membrane-interacting C-terminal domain of the HIV-1 gp41 fusion protein. Several putative transmembrane regions are identified using hydrophobicity analysis based on the Wimley-White scales, including the membrane-proximal external region (MPER). The MPER region is an important target for ne...
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ژورنال
عنوان ژورنال: Retrovirology
سال: 2010
ISSN: 1742-4690
DOI: 10.1186/1742-4690-7-100